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Early Low-dose Ketamine Infusion Versus Usual Care for Sickle Cell Pain Crisis: a Randomized, Prospective Study.

The purpose of this study is to prospectively study the efficacy of low dose ketamine infusions in treating patients who are admitted to the hospital with a sickle cell pain crisis.

Locations

1 United States site

Age

18 to 70 Years

Phase

Phase 4

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Dronabinol for Pain and Inflammation in Adults Living With Sickle Cell Disease

This study is designed to address the feasibility of a randomized, double masked, cross-over study of dronabinol as a palliative agent in the treatment of pain, inflammation, and other complications of sickle cell disease (SCD).

Locations

1 United States site

Age

> 18 Years

Phase

Phase 1

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A Pilot Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Escalating Multiple Oral Doses of AG-348 in Subjects With Stable Sickle Cell Disease

Background: Sickle Cell Disease (SCD) is an inherited blood disorder.

Locations

1 United States site

Age

18 to 70 Years

Phase

Phase 1

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IMatinib for PAin in Chronic Treatment of Sickle Cell Anemia (IMPACT SCA): A Pilot Study of Imatinib in Patients With Sickle Cell Anemia and Recurrent Vaso-occlusive Pain

In this protocol, the investigators propose to evaluate the biochemical effects of imatinib on sickle red blood cells (RBCs).

Locations

1 United States site

Age

18 to 25 Years

Genotypes

SS

Phase

Early Phase 1

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Evaluation of the Interest of Pulmonary Ultrasound in the Diagnosis and Early Detection of Acute Thoracic Syndrome in Hospitalized Children for Vaso-occlusive Sickle Cell Crisis: Multicenter Prospective Study

ATS (acute thoracic syndrome) refers to acute pulmonary involvement in a sickle cell patient.

Locations

4 France sites

Age

12 to 17 Years

Phase

N/A

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Effect of MitoQ on Platelet Function and Reactive Oxygen Species (ROS) Generation in Patients With Sickle Cell Anemia

MitoQ is commercially available as a dietary supplement and it has been tested as a potential drug in other diseases, but it has never been tested in patients with sickle cell disease.

Locations

5 United States sites

Age

> 18 Years

Phase

N/A

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Effect of Salbutamol on Autonomic Nervous System Dysfunction of Children With Sickle Cell Disease

Sickle cell disease (SCD) children and adults with asthma have an increased rate of vaso-occlusive crisis, acute chest syndrome episodes, and premature mortality when compared to those without asthma.

Locations

1 France site

Age

6 to 16 Years

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Validation d’Une Stratégie de Programme Transfusionnel Par Erythraphérèse basée Sur un Algorithme d’Aide à la Prescription Transfusionnelle Chez Les Patients Adultes Drépanocytaires

The main objective of this study is to prove the superiority of a procedure which calculates the volume of RBCs to transfuse and the time between apheresis based on this algorithm, compared to the current procedure.

Locations

7 France sites, 1 Martinique site

Age

> 18 Years

Genotypes

SS

Phase

N/A

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Incentive Spirometry and Pain in the Decompensation of Sickle Cell Disease: Impact on the Length of Stay. Prospective Observational Study

In this prospective observational study among sickle cell children aged 7 to 17 years, who face many experience of pain, pain will be assessed during incentive spirometry sessions.

Locations

1 France site

Age

7 to 17 Years

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