October, 10 2019

A Comparison of Individualized vs. Weight Based Protocols to Treat Vaso-Occlusive Episodes in Sickle Cell Disease


6 United States sites


> 18 Years


Phase 3

About the study

The purpose of this research study is to compare two different ways to give opioid pain
medicine to treat sickle cell disease pain that is bad enough to go to the emergency
department for treatment. One way uses your weight to decide how much pain medicine to give
you while in the emergency department. This is called weight based treatment. The other way
uses how much pain medicine you take at home and how much medicine you needed during past
emergency department visits to decide how much medicine to give you. This is called patient
specific treatment.

Study Type



Phase 3


> 18 Years



Inclusion Criteria

– All adult (18 years or older);

– SCD patients with the following genotypes: Hgb SS, SC, and SB+ and SB- thalassemia

Exclusion Criteria

– determined to not benefit from opioids and therefore won’t receive opioids in any
future ED visit.


  • Other
  • Drug

Outcome measures

  • Change in pain scores as measured by patient reported pain level.


  • University of Maryland, Baltimore, Maryland, United States, 21201 [Recruiting]
  • Henry Ford Health System, Detroit, Michigan, United States, 48202 [Recruiting]
  • Wayne State University, Detroit, Michigan, United States, 48202 [Not yet recruiting]
  • Atrium Health, Charlotte, North Carolina, United States, 28204 [Recruiting]
  • Case Western University, Cleveland, Ohio, United States, 44106 [Recruiting]
  • University of Texas Southwestern Medical Center, Dallas, Texas, United States, 75390 [Not yet recruiting]

Contact Research Team

  • Beth Martinez

More info

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